![]() ![]() (3) Genetic analysis suggests that the cytoplasmic factor of the egg and the factor in spermatozoa are both controlled by autosomal genes located at the same locus or closely linked. A common feature of the dead embryos was a defect in trophoblast formation. (2) Reduction of litter size in the semi-sterile backcrosses was found to be caused by embryonic death at the morula-blastocyst and pre-egg cylinder stages at or around the time of implantation. (1) In reciprocal backcrosses involving DDK mice and three other inbred strains, embryonic survival was halved when DDK females were mated with F 1 males, or when F 1 females of DDK and two other strains were mated with males of the corresponding strains, compared to the results of matings of F 1 females with DDK males. The factors in the eggs of DDK mice and in alien spermatozoa which are responsible for embryonic death in DDK females mated with males from other strains were subjected to genetic analysis. ![]()
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