![]() ![]() MC was processed by the solution enhanced dispersion by supercritical fluids (SEDS) technique obtaining a particle average size of 2.29 µm (8 MPa and 35 ☌), which means a reduction of 5.4 times. In this study, we compared the in vitro antioxidant effects of curcumin (CUR) and micronized curcumin (MC) and studied their effects on behavioral and neurochemical parameters in zebrafish submitted to unpredictable chronic stress (UCS). The process of micronization can overcome this barrier by reducing the particle size and increasing the dissolution rate, potentially improving the bioavailability of the compounds of interest. However, its low bioavailability is a limitation for its potential adoption as a therapeutic agent. (Zingiberaceae), is shown to have antioxidant, anti-inflammatory, neuroprotective, anxiolytic, and antidepressant properties in both preclinical and clinical studies. Curcumin, a polyphenol extracted from the rhizome of Curcuma longa L. ![]()
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